Target：FX

Fields：Fructose and mannose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Biosynthesis of nucleotide sugars

Gene Name：TSTA3

Protein Name：GDP-L-fucose synthase

Human Gene Id：7264

Human Swiss Prot No：Q13630

Mouse Gene Id：22122

Mouse Swiss Prot No：P23591

Immunogen：The antiserum was produced against synthesized peptide derived from human TSTA3. AA range:221-270

Specificity：FX Polyclonal Antibody detects endogenous levels of FX protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TSTA3;SDR4E1;GDP-L-fucose synthase;GDP-4-keto-6-deoxy-D-mannose-3;5-epimerase-4-reductase;Protein FX;Red cell NADP(H)-binding protein;Short-chain dehydrogenase/reductase family 4E member 1

Observed Band(KD)：40kD

Background： Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq, Jul 2008],

Function：catalytic activity:GDP-L-fucose + NADP(+) = GDP-4-dehydro-6-deoxy-D-mannose + NADPH.,function:Two step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.,pathway:Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-D-mannose: step 2/2.,similarity:Belongs to the fucose synthetase family.,subunit:Homodimer.,

Subcellular Location：cytoplasm,cytosol,extracellular exosome,

Expression： Erythrocyte,Lung,Placenta,Skin,