Target:PFK-C
Fields:Glycolysis / Gluconeogenesis;Pentose phosphate pathway;Fructose and mannose metabolism;Galactose metabolism;Metabolic pathways;Carbon metabolism;Biosynthesis of amino acids;RNA degradation;HIF-1 signaling pathway;AMPK signaling pathway;Thyroid hormone signaling pathway;Glucagon signaling pathway;Central carbon metabolism in cancer
Gene Name:PFKP
Protein Name:6-phosphofructokinase type C
Human Gene Id:5214
Human Swiss Prot No:Q01813
Mouse Gene Id:56421
Mouse Swiss Prot No:Q9WUA3
Rat Gene Id:60416
Rat Swiss Prot No:P47860
Immunogen:The antiserum was produced against synthesized peptide derived from human K6PP. AA range:341-390
Specificity:PFK-C Polyclonal Antibody detects endogenous levels of PFK-C protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:PFKP;PFKF;6-phosphofructokinase type C;6-phosphofructokinase; platelet type;Phosphofructo-1-kinase isozyme C;PFK-C;Phosphofructokinase 1;Phosphohexokinase
Observed Band(KD):84kD
Background: This gene encodes a member of the phosphofructokinase A protein family. The encoded enzyme is the platelet-specific isoform of phosphofructokinase and plays a key role in glycolysis regulation. This gene may play a role in metabolic reprogramming in some cancers, including clear cell renal cell carcinomas, and cancer of the bladder, breast, and lung. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016],
Function:catalytic activity:ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.,cofactor:Magnesium.,enzyme regulation:Allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or citrate.,miscellaneous:In human PFK exists as a system of 3 types of subunits, PFKM (muscle), PFKL (liver) and PFKP (platelet) isoenzymes.,pathway:Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.,similarity:Belongs to the phosphofructokinase family. Two domains subfamily.,subunit:Tetramer. Muscle is M4, liver is L4, and red cell is M3L, M2L2, or ML3. A subunit composition with a higher proportion of platelet type subunits is found in platelets, brain and fibroblasts.,
Subcellular Location:Cytoplasm .
Expression: Brain,Epithelium,Kidney,Pancreatic islet,Placenta,Prostate,