Main Information

Target

Claudin-2

Host Species

Mouse

Reactivity

Human, Mouse, Rat

Applications

WB, IF, IHC

MW

25kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:500-2000; IF/ICC1:200-400; IHC

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human Claudin-2

Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

25kD

Modification

Unmodified

Clonality

Monoclonal

Clone Number

8H11

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human Claudin-2

Specificity:

This antibody detects endogenous levels of human Claudin-2

Gene Name:

CLDN2 PSEC0059 SP82 UNQ705/PRO1356

Protein Name:

Claudin-2

Other Name:

Claudin-2 ;
SP82 ;

Database Link:

Organism	Gene ID	SwissProt
Human	9075;	P57739;

Background:

This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010],

Function:

Function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,subunit:Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,

Cellular Localization:

Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein .

Tissue Expression:

Colon,Colon epithelium,Kidney,Skin,Teratocarcinoma,Thalamus,

Research Areas:

>>Cell adhesion molecules ;
>>Tight junction ;
>>Leukocyte transendothelial migration ;
>>Pathogenic Escherichia coli infection ;
>>Hepatitis C