Main Information

Target

Transferrin

Host Species

Mouse

Reactivity

Human

Applications

IHC, IF, ELISA

MW

77kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:100-200; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

Transferrin protein detects endogenous levels of Transferrin

Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

77kD

Modification

Unmodified

Clonality

Monoclonal

Clone Number

2F2

Antigen&Target Information

Immunogen:

Protein

Specificity:

Transferrin protein detects endogenous levels of Transferrin

Gene Name:

TF

Protein Name:

Serotransferrin (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin)

Other Name:

TF ;
Serotransferrin ;
Transferrin ;
Beta-1 metal-binding globulin ;
Siderophilin

Database Link:

Organism	Gene ID	SwissProt
Human	7018;	P02787;
Mouse		Q921I1;

Background:

transferrin(TF) Homo sapiens This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009],

Function:

Disease:Defects in TF are the cause of atransferrinemia [MIM:209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.,Function:Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.,online information:Transferrin entry,polymorphism:Different polymorphic variants of transferrin are known. The sequence shown is the predominant electrophoretic variant (C1 or TF*C1).,similarity:Belongs to the transferrin family.,similarity:Contains 2 transferrin-like domains.,subunit:Monomer.,tissue specificity:Expressed by the liver and secreted in plasma.,

Cellular Localization:

Secreted.

Tissue Expression:

Expressed by the liver and secreted in plasma.

Research Areas:

>>HIF-1 signaling pathway ;
>>Ferroptosis ;
>>Mineral absorption