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Histone H3 (Acetyl Lys18) Polyclonal Antibody
Histone H3 (Acetyl Lys18) Polyclonal Antibody
Histone H3 (Acetyl Lys18) Polyclonal Antibody
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Target:Histone H3

Fields:Neutrophil extracellular trap formation;Alcoholism;Shigellosis;Transcriptional misregulation in cancer;Systemic lupus erythematosus

Gene Name:HIST1H3A/HIST1H3B/HIST1H3C/HIST1H3D/HIST1H3E/HIST1H3F/HIST1H3G/HIST1H3H/HIST1H3I/HIST1H3J/HIST2H3A/HIST2H3C/HIST2H3D/H3F3A/H3F3B

Protein Name:Histone H3.1/Histone H3.2/Histone H3.3

Human Gene Id:8350/8351/8352/8353/8354/8355/8356/8357/8358/8968/126961/333932/653604/3020/3021

Human Swiss Prot No:P68431/Q71DI3/P84243

Mouse Gene Id:319152/15077/15078

Rat Gene Id:291159/100361558

Rat Swiss Prot No:Q6LED0/P84245

Immunogen:The antiserum was produced against synthesized peptide derived from human Histone H3 around the acetylated site of Lys18. AA range:1-50

Specificity:Acetyl-Histone H3 (K18) Polyclonal Antibody detects endogenous levels of Histone H3 protein only when acetylated at K18.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source:Polyclonal, Rabbit,IgG

Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration:1 mg/ml

Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name:HIST1H3A;H3FA;HIST1H3B;H3FL;HIST1H3C;H3FC;HIST1H3D;H3FB;HIST1H3E;H3FD;HIST1H3F;H3FI;HIST1H3G;H3FH;HIST1H3H;H3FK;HIST1H3I;H3FF;HIST1H3J;H3FJ;Histone H3.1;Histone H3/a;Histone H3/b;Histone H3/c;Histone H3/d;Histone H3;H3k18AC

Observed Band(KD):17kD

Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015],

Function:caution:Was originally (PubMed:2587222) thought to originate from mouse.,developmental stage:Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.,function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,mass spectrometry:Monoisotopic with N-acetylserine PubMed:16457589,miscellaneous:This histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation of Lys-10 (H3K9me2).,PTM:Acetylation is generally l

Subcellular Location:Nucleus. Chromosome.

Expression: Blood,Epithelium,Kidney,Lung,Ovary,Spleen,Uterus,

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