Target:Cyclophilin B
Gene Name:PPIB
Protein Name:Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)
Human Gene Id:5479
Human Swiss Prot No:P23284
Mouse Swiss Prot No:P24369
Rat Swiss Prot No:P24368
Immunogen:Synthetic Peptide of Cyclophilin B
Specificity:Cyclophilin B protein detects endogenous levels of Cyclophilin B
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Monoclonal, Mouse
Dilution:WB 1:1000-2000, IHC 1:100-200. IF 1:50-200
Purification:The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:PPIB;CYPB;Peptidyl-prolyl cis-trans isomerase B;PPIase B;CYP-S1;Cyclophilin B;Rotamase B;S-cyclophilin;SCYLP
Observed Band(KD):21kD
Background: The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009],
Function:catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,caution:It is uncertain whether Met-1 or Met-9 is the initiator.,enzyme regulation:Cyclosporin A (CsA) inhibits CYPB.,function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,similarity:Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.,similarity:Contains 1 PPIase cyclophilin-type domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,
Subcellular Location:Virion . (Microbial infection).; Endoplasmic reticulum lumen . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .
Expression: Brain,Fetal brain cortex,Prostate,Skin,