Target：SORC3

Gene Name：SORCS3 KIAA1059

Protein Name：VPS10 domain-containing receptor SorCS3

Human Gene Id：22986

Human Swiss Prot No：Q9UPU3

Mouse Swiss Prot No：Q8VI51

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：SORC3 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：134kD

Background： This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in cell culture results in an increase in amyloid pre

Function：similarity:Contains 1 PKD domain.,similarity:Contains 6 BNR repeats.,tissue specificity:Highly expressed in brain.,

Subcellular Location：Membrane; Single-pass type I membrane protein.

Expression：Highly expressed in brain.