Target：SNM1B

Gene Name：DCLRE1B

Protein Name：5' exonuclease Apollo

Human Gene Id：64858

Human Swiss Prot No：Q9H816

Mouse Swiss Prot No：Q8C7W7

Immunogen：Synthesized peptide derived from the C-terminal region of human SNM1B.

Specificity：SNM1B Polyclonal Antibody detects endogenous levels of SNM1B protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：DCLRE1B;SNM1B;5' exonuclease Apollo;DNA cross-link repair 1B protein;SNM1 homolog B;SNMIB;hSNM1B

Observed Band(KD)：60kD

Background： DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]).[supplied by OMIM, Mar 2008],

Function：function:May be required for DNA interstrand cross-link repair.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.,subcellular location:Localizes to discrete foci.,

Subcellular Location：Chromosome, telomere. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Mainly localizes to telomeres, recruited via its interaction with TERF2. During mitosis, localizes to the centrosome.

Expression： Placenta,Retinoblastoma,Teratocarcinoma,