Target：Snk

Fields：FoxO signaling pathway

Gene Name：PLK2

Protein Name：Serine/threonine-protein kinase PLK2

Human Gene Id：10769

Human Swiss Prot No：Q9NYY3

Mouse Gene Id：20620

Mouse Swiss Prot No：P53351

Rat Gene Id：83722

Rat Swiss Prot No：Q9R012

Immunogen：The antiserum was produced against synthesized peptide derived from human PLK2. AA range:291-340

Specificity：Snk Polyclonal Antibody detects endogenous levels of Snk protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000; IF ICC 1:50-200;ELISA 1:2000-20000;IHC 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PLK2;SNK;Serine/threonine-protein kinase PLK2;Polo-like kinase 2;PLK-2;hPlk2;Serine/threonine-protein kinase SNK;hSNK;Serum-inducible kinase

Observed Band(KD)：78kD

Background： The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:May play a role in the division of at least some cell types, such as fibroblasts, and could function in embryogenesis, wound healing or neoplasia.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 POLO box domains.,

Subcellular Location：Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cell projection, dendrite . Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase.

Expression：Expressed at higher level in the fetal lung, kidney, spleen and heart.