Target：SMUG1
Fields：Base excision repair
Gene Name：SMUG1
Protein Name：Single-strand selective monofunctional uracil DNA glycosylase
Human Gene Id：23583
Human Swiss Prot No：Q53HV7
Mouse Gene Id：71726
Mouse Swiss Prot No：Q6P5C5
Rat Gene Id：315344
Rat Swiss Prot No：Q811Q1
Immunogen：The antiserum was produced against synthesized peptide derived from human SMUG1. AA range:91-140
Specificity：SMUG1 Polyclonal Antibody detects endogenous levels of SMUG1 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：SMUG1;Single-strand selective monofunctional uracil DNA glycosylase
Observed Band(KD)：32kD
Background： This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the full-length nature is known for some but not all of the variants. [provided by RefSeq, Aug 2011],
Function：function:Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA.,
Subcellular Location：Nucleus .
Expression： Adipose tissue,Brain,Liver,Muscle,Ovary,Ute
