Target：SLK

Fields：Oocyte meiosis

Gene Name：SLK

Protein Name：STE20-like serine/threonine-protein kinase

Human Gene Id：9748

Human Swiss Prot No：Q9H2G2

Mouse Gene Id：20874

Mouse Swiss Prot No：O54988

Rat Gene Id：54308

Rat Swiss Prot No：O08815

Immunogen：The antiserum was produced against synthesized peptide derived from human SLK. AA range:1151-1200

Specificity：SLK Polyclonal Antibody detects endogenous levels of SLK protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SLK;KIAA0204;STK2;STE20-like serine/threonine-protein kinase;STE20-like kinase;hSLK;CTCL tumor antigen se20-9;STE20-related serine/threonine-protein kinase;STE20-related kinase;Serine/threonine-protein kinase 2

Observed Band(KD)：150kD

Background：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Mediates apoptosis and actin stress fiber dissolution.,PTM:Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Proteolytically cleaved by caspase-3.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 422.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 611.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 614.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UVR domain.,tissue specificity:Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle.,

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Mediates apoptosis and actin stress fiber dissolution.,PTM:Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Proteolytically cleaved by caspase-3.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 422.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 611.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 614.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UVR domain.,tissue specificity:Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle.,

Subcellular Location：Cytoplasm .

Expression：Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle.