Target：Hic-5

Gene Name：TGFB1I1

Protein Name：Transforming growth factor beta-1-induced transcript 1 protein

Human Gene Id：7041

Human Swiss Prot No：O43294

Mouse Gene Id：21804

Mouse Swiss Prot No：Q62219

Rat Gene Id：84574

Rat Swiss Prot No：Q99PD6

Immunogen：The antiserum was produced against synthesized peptide derived from human Hic-5. AA range:31-80

Specificity：Hic-5 Polyclonal Antibody detects endogenous levels of Hic-5 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TGFB1I1;ARA55;Transforming growth factor beta-1-induced transcript 1 protein;Androgen receptor coactivator 55 kDa protein;Androgen receptor-associated protein of 55 kDa;Hydrogen peroxide-inducible clone 5 protein;Hic-5

Molecular Weight(Da)：50kD

Background：transforming growth factor beta 1 induced transcript 1(TGFB1I1) Homo sapiens This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],

Function：domain:The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal.,domain:The LIM zinc-binding domains mediate glucocorticoid receptor coactivation and interaction with AR, CRIP2, ILK, LIMS1, NR3C1, PPARG, TCF3, TCF7L2, SLC6A3 and SMAD3. The LIM zinc-binding 2 and LIM zinc-binding 3 domains mediate targeting to focal adhesions and actin stress fibers. The LIM zinc-binding 3 and LIM zinc-binding 4 domains mediate interaction with TRAF4 and MAPK15. The LIM zinc-binding 4 domain mediates interaction with HSPB1, homooligomerization and targeting to the nuclear matrix. The LIM zinc-binding 3 domain mediates interaction with PTPN12.,function:Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane

Subcellular Location：Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Associated with the actin cytoskeleton; colocalizes with stress fibers.

Expression：Expressed in platelets, smooth muscle and prostate stromal cells (at protein level).