Target：Scn4b

Fields：Adrenergic signaling in cardiomyocytes

Gene Name：SCN4B

Protein Name：Sodium channel subunit beta-4

Human Gene Id：6330

Human Swiss Prot No：Q8IWT1

Mouse Swiss Prot No：Q7M729

Immunogen：The antiserum was produced against synthesized peptide derived from human SCN4B. AA range:61-110

Specificity：Scn4b Polyclonal Antibody detects endogenous levels of Scn4b protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SCN4B;Sodium channel subunit beta-4

Observed Band(KD)：27kD

Background： The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009],

Function：disease:Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy.,function:Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation.,PTM:Contains a number of interchain disulfide bonds with SCN2A.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,subunit:The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-

Subcellular Location：Cell membrane ; Single-pass type I membrane protein .

Expression：Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium.