Target：Hepatic Lipase

Fields：Glycerolipid metabolism;Metabolic pathways;Cholesterol metabolism

Gene Name：LIPC

Protein Name：Hepatic triacylglycerol lipase

Human Gene Id：3990

Human Swiss Prot No：P11150

Mouse Swiss Prot No：P27656

Immunogen：The antiserum was produced against synthesized peptide derived from human LIPC. AA range:301-350

Specificity：Hepatic Lipase Polyclonal Antibody detects endogenous levels of Hepatic Lipase protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：LIPC;HTGL;Hepatic triacylglycerol lipase;HL;Hepatic lipase;Lipase member C

Observed Band(KD)：56kD

Background： LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008],

Function：catalytic activity:Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.,disease:Defects in LIPC are the cause of hepatic lipase deficiency (HL deficiency) [MIM:151670].,function:Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the AB hydrolase superfamily. Lipase family.,similarity:Contains 1 PLAT domain.,

Subcellular Location：Secreted .

Expression： Donated clones,Liver,Thymus,