Target：SAMHD1

Fields：Viral life cycle - HIV-1;Human immunodeficiency virus 1 infection

Gene Name：SAMHD1

Protein Name：SAM domain and HD domain-containing protein 1

Human Gene Id：25939

Human Swiss Prot No：Q9Y3Z3

Mouse Gene Id：56045

Mouse Swiss Prot No：Q60710

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human SAMHD1. AA range:431-480

Specificity：SAMHD1 Polyclonal Antibody detects endogenous levels of SAMHD1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SAMHD1;MOP5;SAM domain and HD domain-containing protein 1;Dendritic cell-derived IFNG-induced protein;DCIP;Monocyte protein 5;MOP-5

Observed Band(KD)：72kD

Background：SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1(SAMHD1) Homo sapiens This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010],

Function：function:May play a role in mediating proinflammatory responses to TNF-alpha signaling.,induction:By interferon gamma. Up-regulated in TNF-alpha treated lung fibroblasts.,similarity:Contains 1 HD domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,tissue specificity:Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus.,

Subcellular Location：Nucleus . Chromosome . Localizes to sites of DNA double-strand breaks in response to DNA damage. .

Expression：Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes (PubMed:11064105). No expression is seen in brain and thymus (PubMed:11064105).