Target：HCN3

Fields：GnRH secretion

Gene Name：HCN3 KIAA1535

Protein Name：Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

Human Gene Id：57657

Human Swiss Prot No：Q9P1Z3

Mouse Swiss Prot No：O88705

Rat Swiss Prot No：Q9JKA8

Immunogen：Synthesized peptide derived from human protein . at AA range: 150-230

Specificity：HCN3 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：85kD

Background： This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],

Function：domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Putative hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions.,similarity:Belongs to the potassium channel HCN family.,similarity:Contains 1 cyclic nucleotide-binding domain.,subunit:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression：Detected in brain.