Target：HCN2

Fields：cAMP signaling pathway;GnRH secretion

Gene Name：HCN2

Protein Name：Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

Human Gene Id：610

Human Swiss Prot No：Q9UL51

Mouse Gene Id：15166

Mouse Swiss Prot No：O88703

Rat Gene Id：114244

Rat Swiss Prot No：Q9JKA9

Immunogen：The antiserum was produced against synthesized peptide derived from human HCN2. AA range:491-540

Specificity：HCN2 Polyclonal Antibody detects endogenous levels of HCN2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：HCN2;BCNG2;Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2;Brain cyclic nucleotide-gated channel 2;BCNG-2

Observed Band(KD)：100kD

Background： Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM, Jul 2010],

Function：domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.,miscellaneous:Inhibited by extracellular cesium ions.,similarity:Belongs to the potassium channel HCN family.,similarity:Contains 1 cyclic nucleotide-binding domain.,subunit:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN1. Interacts with KCNE2.,tissue specificity:Highly expressed throughout the brain. Detected at

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression：Highly expressed throughout the brain. Detected at low levels in heart.