Target：HC-II

Fields：Complement and coagulation cascades

Gene Name：SERPIND1

Protein Name：Heparin cofactor 2

Human Gene Id：3053

Human Swiss Prot No：P05546

Mouse Gene Id：15160

Mouse Swiss Prot No：P49182

Rat Gene Id：79224

Rat Swiss Prot No：Q64268

Immunogen：The antiserum was produced against synthesized peptide derived from human Heparin Cofactor II. AA range:41-90

Specificity：HC-II Polyclonal Antibody detects endogenous levels of HC-II protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SERPIND1;HCF2;Heparin cofactor 2;Heparin cofactor II;HC-II;Protease inhibitor leuserpin-2;HLS2;Serpin D1

Observed Band(KD)：60kD

Background： This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2015],

Function：disease:Defects in SERPIND1 are the cause of heparin cofactor 2 deficiency (HCF2D) [MIM:612356]. HCF2D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis.,domain:The N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition.,function:Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.,function:Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.,similarity:Belongs to the serpin family.,tissue specificity:Expressed predominantly in liver.,

Subcellular Location：extracellular region,extracellular space,extracellular exosome,

Expression：Expressed predominantly in liver. Also present in plasma.