Target：GNAI3

Fields：Rap1 signaling pathway;cGMP-PKG signaling pathway;cAMP signaling pathway;Chemokine signaling pathway;Sphingolipid signaling pathway;Adrenergic signaling in cardiomyocytes;Axon guidance;Apelin signaling pathway;Gap junction;Platelet activation;Leukocyte transendothelial migration;Circadian entrainment;Retrograde endocannabinoid signaling;Glutamatergic synapse;Cholinergic synapse;Serotonergic synapse;GABAergic synapse;Dopaminergic synapse;Long-term depression;Progesterone-mediated oocyte maturation;Estrogen signaling pathway;Melanogenesis;Oxytocin signaling pathway;Regulation of lipolysis in adipocytes;Renin secretion;Relaxin signaling pathway;Parathyroid hormone synthesis, secretion and action;Cushing syndrome;Growth hormone synthesis, secretion and action;Gastric acid secretion;Parkinson disease;Cocaine addiction;Morphine addiction;Alcoholism;Pertussis;Chagas disease;Toxoplasmosis;Human cytomegalovirus infectio

Gene Name：GNAI3

Protein Name：Guanine nucleotide-binding protein G(k) subunit alpha

Human Gene Id：2773

Human Swiss Prot No：P08754

Mouse Gene Id：14679

Mouse Swiss Prot No：Q9DC51

Rat Gene Id：25643

Rat Swiss Prot No：P08753

Immunogen：The antiserum was produced against synthesized peptide derived from human GNAI3. AA range:31-80

Specificity：Gα i-3 Polyclonal Antibody detects endogenous levels of Gα i-3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GNAI3;Guanine nucleotide-binding protein G(k) subunit alpha;G(i) alpha-3

Observed Band(KD)：41kD

Background： Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012],

Function：function:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor-regulated K(+) channels.,similarity:Belongs to the G-alpha family. G(i/o/t/z) subfamily.,subunit:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with GPSM1.,

Subcellular Location：Cytoplasm . Cell membrane ; Lipid-anchor . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody. .

Expression： Liver,