Target：GTSE1

Fields：p53 signaling pathway

Gene Name：GTSE1

Protein Name：G2 and S phase-expressed protein 1 (GTSE-1) (Protein B99 homolog)

Human Gene Id：51512

Human Swiss Prot No：Q9NYZ3

Mouse Swiss Prot No：Q8R080

Immunogen：Synthesized peptide derived from human protein . at AA range: 70-150

Specificity：GTSE1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：79kD

Background： The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008],

Function：developmental stage:Expressed in G2/M phase. Not detected in quiescent cells.,function:May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.,PTM:Phosphorylated in mitosis.,subcellular location:Associated with microtubules.,

Subcellular Location：Cytoplasm, cytoskeleton. Associated with microtubules.

Expression： Brain,Epithelium,Liver,Muscle,Placenta,