Target：Grap
Gene Name：GRAP
Protein Name：GRB2-related adapter protein
Human Gene Id：10750
Human Swiss Prot No：Q13588
Mouse Gene Id：71520
Mouse Swiss Prot No：Q9CX99
Immunogen：The antiserum was produced against synthesized peptide derived from human GRAP. AA range:1-50
Specificity：Grap Polyclonal Antibody detects endogenous levels of Grap protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：GRAP;GRB2-related adapter protein
Observed Band(KD)：28kD
Background： This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012],
Function：function:Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.,similarity:Belongs to the GRB2/sem-5/DRK family.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,subunit:Associates through its SH2 domain with ligand-activated receptors for stem cell factor (KIT) and erythropoietin (EPOR). Also forms a stable complex with the Bcr-Abl oncoprotein. GRAP is associated with the Ras guanine nucleotide exchange factor SOS1, primarily through its N-terminal SH3 domain. Interacts with phosphorylated LAT upon TCR activation. Interacts with SHB.,
Subcellular Location：Membrane ; Peripheral membrane protein . Cell junction, synapse . Localizes at the presynaptic terminal. .
Expression： Blood,Brain,
