Target：Granzyme M

Gene Name：GZMM MET1

Protein Name：Granzyme M (EC 3.4.21.-) (Met-1 serine protease) (Hu-Met-1) (Met-ase) (Natural killer cell granular protease)

Human Gene Id：3004

Human Swiss Prot No：P51124

Immunogen：Synthetic peptide from human protein at AA range: 207-256

Specificity：The antibody detects endogenous Granzyme M

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：Granzyme M (EC 3.4.21.-;Met-1 serine protease;Hu-Met-1;Met-ase;Natural killer cell granular protease)

Background： Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012],

Function：function:Cleaves peptide substrates after methionine, leucine, and norleucine.,similarity:Belongs to the peptidase S1 family. Granzyme subfamily.,similarity:Contains 1 peptidase S1 domain.,subcellular location:Granules of large granular lymphocytes.,

Subcellular Location：Secreted. Cytoplasmic granule. Granules of large granular lymphocytes.

Expression：Highly and constitutively expressed in activated natural killer (NK) cells.