Target：GPR78

Gene Name：GPR78 UNQ5925/PRO19818

Protein Name：G-protein coupled receptor 78

Human Gene Id：27201

Human Swiss Prot No：Q96P69

Immunogen：Synthesized peptide derived from human protein . at AA range: 290-370

Specificity：GPR78 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：39kD

Background： The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an orphan receptor, which displays significant level of constitutive activity. Association analysis shows preliminary evidence for the involvement of this gene in susceptibility to bipolar affective disorder and schizophrenia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011],

Function：function:Orphan receptor.,induction:Expression increased in fibroblasts or HeLa cells following UV-A irradiation, exposure to DNA-alkylating agents, or endoplasmic reticulum (ER) stress caused by osmotic shock or the glycosylation inhibitor tunicamycin.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in pituitary and placenta. No expression detected in brain, skeletal muscle, lung, heart, liver, pancreas, or kidney.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression：High level of expression in placenta. Expressed throughout the brain at low level. No expression detected in skeletal muscle, lung, heart, liver, pancreas, or kidney.