Target：GPR105

Fields：Neuroactive ligand-receptor interaction

Gene Name：P2RY14

Protein Name：P2Y purinoceptor 14

Human Gene Id：9934

Human Swiss Prot No：Q15391

Mouse Gene Id：140795

Mouse Swiss Prot No：Q9ESG6

Rat Gene Id：171108

Rat Swiss Prot No：O35881

Immunogen：The antiserum was produced against synthesized peptide derived from human GPR105. AA range:146-195

Specificity：GPR105 Polyclonal Antibody detects endogenous levels of GPR105 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：P2RY14;GPR105;KIAA0001;P2Y purinoceptor 14;P2Y14;G-protein coupled receptor 105;UDP-glucose receptor

Observed Band(KD)：39kD

Background： The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008],

Function：function:Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Highest expression in the placenta, adipose tissue, stomach and intestine, intermediate levels in the brain, spleen, lung and heart, lowest levels in the kidney.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression：Highest expression in the placenta, adipose tissue, stomach and intestine, intermediate levels in the brain, spleen, lung and heart, lowest levels in the kidney.