Target：USP11

Gene Name：USP11

Protein Name：Ubiquitin carboxyl-terminal hydrolase 11

Human Gene Id：8237

Human Swiss Prot No：P51784

Mouse Gene Id：236733

Mouse Swiss Prot No：Q99K46

Immunogen：Synthesized peptide derived from the Internal region of human USP11.

Specificity：USP11 Polyclonal Antibody detects endogenous levels of USP11 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IF 1:50-200 WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：USP11;UHX1;Ubiquitin carboxyl-terminal hydrolase 11;Deubiquitinating enzyme 11;Ubiquitin thioesterase 11;Ubiquitin-specific-processing protease 11

Observed Band(KD)：105kD

Background： Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq, Jul 2008],

Function：catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 DUSP domain.,subunit:Interacts with RANBP9/RANBPM.,

Subcellular Location：Nucleus . Cytoplasm . Chromosome . Predominantly nuclear (PubMed:12084015, PubMed:15314155). Associates with chromatin (PubMed:20601937, PubMed:20233726). .

Expression： Brain,Fetal brain,Muscle,Retina,