Target：ULK2

Fields：Autophagy - other;Autophagy - animal;mTOR signaling pathway;Alzheimer disease;Amyotrophic lateral sclerosis;Huntington disease;Spinocerebellar ataxia;Pathways of neurodegeneration - multiple diseases

Gene Name：ULK2 KIAA0623

Protein Name：unc-51-like kinase 2 (C. elegans)

Human Gene Id：9706

Human Swiss Prot No：Q8IYT8

Mouse Gene Id：29869

Mouse Swiss Prot No：Q9QY01

Immunogen：Synthetic peptide from human protein at AA range: 930-1000

Specificity：The antibody detects endogenous ULK2 protein

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000, ELISA 1:10000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ULK2 KIAA0623

Observed Band(KD)：140kD

Background：unc-51 like autophagy activating kinase 2(ULK2) Homo sapiens This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.,similarity:Contains 1 protein kinase domain.,

Subcellular Location：Cytoplasmic vesicle membrane ; Peripheral membrane protein . Localizes to pre-autophagosomal membrane.

Expression： Brain,Testis,