Target：RPA40

Fields：RNA polymerase;Cytosolic DNA-sensing pathway

Gene Name：POLR1C

Protein Name：DNA-directed RNA polymerases I and III subunit RPAC1

Human Gene Id：9533

Human Swiss Prot No：O15160

Mouse Gene Id：20016

Mouse Swiss Prot No：P52432

Immunogen：The antiserum was produced against synthesized peptide derived from human POLR1C. AA range:101-150

Specificity：RPA40 Polyclonal Antibody detects endogenous levels of RPA40 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：POLR1C;POLR1E;DNA-directed RNA polymerases I and III subunit RPAC1;DNA-directed RNA polymerase I subunit C;RNA polymerases I and III subunit AC1;AC40;DNA-directed RNA polymerases I and III 40 kDa polypeptide;RPA40;RPA39;RPC40

Observed Band(KD)：39kD

Background： The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Mutations in this gene have been associated with Treacher Collins syndrome (TCS) and hypomyelinating leukodystrophy 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],

Function：function:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft.,similarity:Belongs to the archaeal rpoD/eukaryotic RPB3 RNA polymerase subunit family.,subunit:Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.,

Subcellular Location：Nucleus .

Expression： Brain,Ovarian carcinoma,Placenta,Umbilical cord blood,