Target：CHST9

Fields：Various types of N-glycan biosynthesis;Metabolic pathways

Gene Name：CHST9

Protein Name：Carbohydrate sulfotransferase 9

Human Gene Id：83539

Human Swiss Prot No：Q7L1S5

Mouse Gene Id：71367

Mouse Swiss Prot No：Q76EC5

Immunogen：The antiserum was produced against synthesized peptide derived from human CHST9. AA range:361-410

Specificity：CHST9 Polyclonal Antibody detects endogenous levels of CHST9 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CHST9;Carbohydrate sulfotransferase 9;GalNAc-4-O-sulfotransferase 2;GalNAc-4-ST2;GalNAc4ST-2;N-acetylgalactosamine-4-O-sulfotransferase 2

Molecular Weight(Da)：51kD

Background： The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Sulfate groups on carbohydrates confer highly specific functions to glycoproteins, glycolipids, and proteoglycans, and are critical for cell-cell interaction, signal transduction, and embryonic development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Aug 2011],

Function：caution:It is uncertain whether Met-1 or Met-8 is the initiator.,function:Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin.,similarity:Belongs to the sulfotransferase 2 family.,tissue specificity:Highly expressed in trachea. Also expressed in fetal lung, adult pancreas, testis and salivary gland. Expressed at low level in pituitary gland, apex of the heart, adult lung, prostate and mammary gland. Weakly or not expressed in heart, liver and spinal cord.,

Subcellular Location：[Isoform 1]: Golgi apparatus membrane ; Single-pass type II membrane protein .; [Isoform 2]: Secreted .

Expression：Highly expressed in trachea. Also expressed in fetal lung, adult pancreas, testis and salivary gland. Expressed at low level in pituitary gland, apex of the heart, adult lung, prostate and mammary gland. Weakly or not expressed in heart, liver and spinal cord.