Target：CHST2

Fields：Glycosaminoglycan biosynthesis - keratan sulfate

Gene Name：CHST2

Protein Name：Carbohydrate sulfotransferase 2

Human Gene Id：9435

Human Swiss Prot No：Q9Y4C5

Mouse Swiss Prot No：Q80WV3

Immunogen：The antiserum was produced against synthesized peptide derived from human CHST2. AA range:1-50

Specificity：CHST2 Polyclonal Antibody detects endogenous levels of CHST2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CHST2;GN6ST;Carbohydrate sulfotransferase 2;Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2;GST-2;N-acetylglucosamine 6-O-sulfotransferase 1;GlcNAc6ST-1;Gn6ST-1

Observed Band(KD)：58kD

Background： This locus encodes a sulfotransferase protein. The encoded enzyme catalyzes the sulfation of a nonreducing N-acetylglucosamine residue, and may play a role in biosynthesis of 6-sulfosialyl Lewis X antigen. [provided by RefSeq, Aug 2011],

Function：caution:It is uncertain whether Met-1 or Met-48 is the initiator.,function:Catalyzes the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as L-selectin ligands. L-selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of L-selectin ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains.,induction:Up-regulated upon cytokine activation.,online information:GlycoGene database,similarity:Belongs to the sulfotransferase 1 family.

Subcellular Location：Golgi apparatus, trans-Golgi network membrane ; Single-pass type II membrane protein .

Expression：Widely expressed. Highly expressed in bone marrow, peripheral blood leukocytes, spleen, brain, spinal cord, ovary and placenta. Expressed by high endothelial cells (HEVs) and leukocytes.