Target：Cerebellin 1

Gene Name：CBLN1

Protein Name：Cerebellin-1

Human Gene Id：869

Human Swiss Prot No：P23435

Mouse Gene Id：12404

Mouse Swiss Prot No：Q9R171

Rat Gene Id：498922

Rat Swiss Prot No：P63182

Immunogen：The antiserum was produced against synthesized peptide derived from human CBLN1. AA range:131-180

Specificity：Cerebellin 1 Polyclonal Antibody detects endogenous levels of Cerebellin 1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CBLN1;Cerebellin-1;Precerebellin

Observed Band(KD)：25kD

Background： This gene encodes a cerebellum-specific precursor protein, precerebellin, with similarity to the globular (non-collagen-like) domain of complement component C1qB. Precerebellin is processed to give rise to several derivatives, including the hexadecapeptide, cerebellin, which is highly enriched in postsynaptic structures of Purkinje cells. Cerebellin has also been found in human and rat adrenals, where it has been shown to enhance the secretory activity of this gland. [provided by RefSeq, Aug 2008],

Function：developmental stage:Low at birth, the cerebellin concentration increases between day 5 and 15, and reaches peak values between day 21 and 56.,function:Cerebellin exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release.,function:Cerebellin-1 is required for synapse integrity and synaptic plasticity. Required for the ER export and secretion of CBLN3.,PTM:The proteolytic processing to yield cerebellin seems to occur either prior to the secretion by presynaptic neurons and subsequent oligomerization or in some other location after release of the mature protein.,similarity:Contains 1 C1q domain.,subcellular location:Might be bound to, or associated with, a membrane.,subunit:Homohexamer;

Subcellular Location：Secreted . Cell junction, synapse, postsynaptic cell membrane .

Expression：In the Purkinje cells postsynaptic structures. In the cerebellum, cerebellin is much less abundant than [des-Ser1]-cerebellin.