Target：LTOR3
Fields：MAPK signaling pathway;mTOR signaling pathway
Gene Name：LAMTOR3 MAP2K1IP1 MAPKSP1 PRO2783
Protein Name：Ragulator complex protein LAMTOR3 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3) (MEK-binding partner 1) (Mp1) (Mitogen-activated protein kinase kinase 1-interacting protein 1) (Mito
Human Gene Id：8649
Human Swiss Prot No：Q9UHA4
Mouse Swiss Prot No：O88653
Rat Swiss Prot No：Q5U204
Immunogen：Synthesized peptide derived from human protein . at AA range: 30-110
Specificity：LTOR3 Polyclonal Antibody detects endogenous levels of protein.
Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 ELISA 1:5000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)：13kD
Background： This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011],
Function：function:Adapter protein that enhances the efficiency of the MAP kinase cascade. Facilitates the activation of MAPK2.,similarity:Belongs to the MAPKSP1 family.,subunit:Interacts with MAP2K1 and MAPK2. Interacts with MORG1 (By similarity). Heterodimer with MAPBPIP.,
Subcellular Location：Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side .
Expression： Brain,Dendritic cell,Fetal liver,Liver,Lung
