Target：LTOR2

Fields：mTOR signaling pathway

Gene Name：LAMTOR2 MAPBPIP ROBLD3 HSPC003

Protein Name：Ragulator complex protein LAMTOR2 (Endosomal adaptor protein p14) (Late endosomal/lysosomal Mp1-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2) (Mitogen-activated

Human Gene Id：28956

Human Swiss Prot No：Q9Y2Q5

Mouse Swiss Prot No：Q9JHS3

Immunogen：Synthesized peptide derived from human protein . at AA range: 10-90

Specificity：LTOR2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：13kD

Background： The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009],

Function：disease:Defects in ROBLD3 are the cause of immunodeficiency due to defect in MAPBP-interacting protein [MIM:610798]. This form of primary immunodeficiency syndrome includes congenital neutropenia, partial albinism, short stature and B-cell and cytotoxic T-cell deficiency.,function:Adapter protein that enhances the efficiency of the MAP kinase cascade. Facilitates the activation of MAPK2.,online information:ROBLD3 mutation db,similarity:Belongs to the GAMAD family.,subunit:Heterodimer with MAP2K1IP1. Interacts with MAPK1 and MAP2K1.,

Subcellular Location：Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side .

Expression： Lung,Umbilical cord blood,