Target：CdcA3

Gene Name：CDCA3

Protein Name：Cell division cycle-associated protein 3

Human Gene Id：83461

Human Swiss Prot No：Q99618

Mouse Gene Id：14793

Mouse Swiss Prot No：Q99M54

Rat Gene Id：297594

Rat Swiss Prot No：Q68FW2

Immunogen：The antiserum was produced against synthesized peptide derived from human CDCA3. AA range:219-268

Specificity：CdcA3 Polyclonal Antibody detects endogenous levels of CdcA3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CDCA3;C8;GRCC8;TOME1;Cell division cycle-associated protein 3;Gene-rich cluster protein C8;Trigger of mitotic entry protein 1;TOME-1

Observed Band(KD)：28kD

Background：domain:The KEN box is required for the association with the APC/C-Cdh1 complex.,function:F-box-like protein which is required for entry into mitosis. Acts by participating to E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Ubiquitinated and degraded by the APC/C-Cdh1 complex.,subunit:Interacts with SKP1A. Part of a SCF (SKP1-cullin-F-box) protein ligase complex.,

Function：domain:The KEN box is required for the association with the APC/C-Cdh1 complex.,function:F-box-like protein which is required for entry into mitosis. Acts by participating to E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Ubiquitinated and degraded by the APC/C-Cdh1 complex.,subunit:Interacts with SKP1A. Part of a SCF (SKP1-cullin-F-box) protein ligase complex.,

Subcellular Location：Cytoplasm, cytosol .

Expression： Brain,Placenta,Testis,Thymus,