Target：Cdc7
Fields：Cell cycle
Gene Name：CDC7
Protein Name：Cell division cycle 7-related protein kinase
Human Gene Id：8317
Human Swiss Prot No：O00311
Mouse Swiss Prot No：Q9Z0H0
Immunogen：The antiserum was produced against synthesized peptide derived from human CDC7. AA range:1-50
Specificity：Cdc7 Polyclonal Antibody detects endogenous levels of Cdc7 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：CDC7;CDC7L1;Cell division cycle 7-related protein kinase;CDC7-related kinase;HsCdc7;huCdc7
Observed Band(KD)：70kD
Background： This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008],
Function：alternative products:A number of isoforms may be produced,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,function:Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Forms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity.,
Subcellular Location：Nucleus.
Expression： Brain,Embryonal rhabdomyosarcoma,Liver,Testis,
