Target：L-type Ca++ CP γ7

Fields：MAPK signaling pathway;Cardiac muscle contraction;Adrenergic signaling in cardiomyocytes;Oxytocin signaling pathway;Hypertrophic cardiomyopathy;Arrhythmogenic right ventricular cardiomyopathy;Dilated cardiomyopathy

Gene Name：CACNG7

Protein Name：Voltage-dependent calcium channel gamma-7 subunit

Human Gene Id：59284

Human Swiss Prot No：P62955

Mouse Gene Id：81904

Mouse Swiss Prot No：P62956

Rat Gene Id：140728

Rat Swiss Prot No：P62957

Immunogen：The antiserum was produced against synthesized peptide derived from human CACNG7. AA range:198-247

Specificity：L-type Ca++ CP γ7 Polyclonal Antibody detects endogenous levels of L-type Ca++ CP γ7 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CACNG7;Voltage-dependent calcium channel gamma-7 subunit;Neuronal voltage-gated calcium channel gamma-7 subunit;Transmembrane AMPAR regulatory protein gamma-7;TARP gamma-7

Observed Band(KD)：40kD

Background：calcium voltage-gated channel auxiliary subunit gamma 7(CACNG7) Homo sapiens The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010],

Function：function:Thought to stabilize the calcium channel in an inactivated (closed) state.,similarity:Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.,subunit:The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.,tissue specificity:Widely expressed.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression：Detected in heart left ventricle (PubMed:21127204). Widely expressed.