Target：LT-β

Fields：Cytokine-cytokine receptor interaction;NF-kappa B signaling pathway;Rheumatoid arthritis

Gene Name：LTB

Protein Name：Lymphotoxin-beta

Human Gene Id：4050

Human Swiss Prot No：Q06643

Mouse Gene Id：16994

Mouse Swiss Prot No：P41155

Immunogen：The antiserum was produced against synthesized peptide derived from human TNFC. AA range:181-230

Specificity：LT-β Polyclonal Antibody detects endogenous levels of LT-β protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：LTB;TNFC;TNFSF3;Lymphotoxin-beta;LT-beta;Tumor necrosis factor C;TNF-C;Tumor necrosis factor ligand superfamily member 3

Observed Band(KD)：22kD

Background： Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

Function：function:Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.,similarity:Belongs to the tumor necrosis factor family.,subunit:Heterotrimer of either two LTB and one LTA subunits or (less prevalent) one LTB and two LTA subunits.,tissue specificity:Spleen and thymus.,

Subcellular Location：Membrane ; Single-pass type II membrane protein .

Expression：Spleen and thymus.