Target：LTβR

Fields：Cytokine-cytokine receptor interaction;Viral protein interaction with cytokine and cytokine receptor;NF-kappa B signaling pathway;HIF-1 signaling pathway;Intestinal immune network for IgA production;Human T-cell leukemia virus 1 infection;Viral carcinogenesis

Gene Name：LTBR

Protein Name：Tumor necrosis factor receptor superfamily member 3

Human Gene Id：4055

Human Swiss Prot No：P36941

Mouse Gene Id：17000

Mouse Swiss Prot No：P50284

Immunogen：The antiserum was produced against synthesized peptide derived from human LTBR. AA range:11-60

Specificity：LTβR Polyclonal Antibody detects endogenous levels of LTβR protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：LTBR;D12S370;TNFCR;TNFR3;TNFRSF3;Tumor necrosis factor receptor superfamily member 3;Lymphotoxin-beta receptor;Tumor necrosis factor C receptor;Tumor necrosis factor receptor 2-related protein;Tumor necrosis factor receptor type II

Observed Band(KD)：50kD

Background：lymphotoxin beta receptor(LTBR) Homo sapiens This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012],

Function：function:Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Self-associates. Associates with TRAF3, TRAF4 and TRAF5. Interacts with HCV core protein.,

Subcellular Location：Membrane; Single-pass type I membrane protein.

Expression： Liver,Lung,