Target：LUM
Fields：Proteoglycans in cancer
Gene Name：LUM LDC SLRR2D
Protein Name：Lumican (Keratan sulfate proteoglycan lumican) (KSPG lumican)
Human Gene Id：4060
Human Swiss Prot No：P51884
Mouse Swiss Prot No：P51885
Rat Swiss Prot No：P51886
Immunogen：Synthesized peptide derived from human protein . at AA range: 30-110
Specificity：LUM Polyclonal Antibody detects endogenous levels of protein.
Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 ELISA 1:5000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)：37kD
Background： This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008],
Function：developmental stage:Present in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the adult. In the adult cartilage lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan.,PTM:Sulfated on tyrosine residue(s).,similarity:Belongs to the small leucine-rich proteoglycan (SLRP) family. Class II subfamily.,similarity:Contains 12 LRR (leucine-rich) repeats.,subunit:Binds to laminin.,tissue specificity:Cornea and other tissues.,
Subcellular Location：Secreted, extracellular space, extracellular matrix .
Expression：Cornea and other tissues.
