Target：LWS
Fields：PPAR signaling pathway;Th17 cell differentiation;Thyroid hormone signaling pathway;Adipocytokine signaling pathway;Parathyroid hormone synthesis, secretion and action;Pathways in cancer;Transcriptional misregulation in cancer;Chemical carcinogenesis - receptor activation;Thyroid cancer;Small cell lung cancer;Non-small cell lung cancer;Gastric cancer;Lipid and atherosclerosis
Gene Name：RXRG NR2B3
Protein Name：LWS
Human Gene Id：6258
Human Swiss Prot No：P48443
Mouse Gene Id：20183
Mouse Swiss Prot No：P28705
Immunogen：Synthesized peptide derived from human LWS. at AA range: 380-420
Specificity：This antibody detects endogenous levels of LWS
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000, ELISA 1:10000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：Retinoic acid receptor RXR-gamma (Nuclear receptor subfamily 2 group B member 3) (Retinoid X receptor gamma)
Observed Band(KD)：50kD
Background：retinoid X receptor gamma(RXRG) Homo sapiens This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010],
Function：caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,function:Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA).,similarity:Belongs to the nuclear hormone receptor family. NR2 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,
Subcellular Location：Nucleus . Cytoplasm .
Expression：Expressed in aortic endothelial cells (at protein level).
