Target：Lyl-1

Fields：Transcriptional misregulation in cancer

Gene Name：LYL1

Protein Name：Protein lyl-1

Human Gene Id：4066

Human Swiss Prot No：P12980

Mouse Gene Id：17095

Mouse Swiss Prot No：P27792

Rat Gene Id：304663

Rat Swiss Prot No：Q66HH3

Immunogen：The antiserum was produced against synthesized peptide derived from human Lyl-1. AA range:151-200

Specificity：Lyl-1 Polyclonal Antibody detects endogenous levels of Lyl-1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：LYL1;BHLHA18;Protein lyl-1;Class A basic helix-loop-helix protein 18;bHLHa18;Lymphoblastic leukemia-derived sequence 1

Molecular Weight(Da)：29kD

Background： This gene represents a basic helix-loop-helix transcription factor. The encoded protein may play roles in blood vessel maturation and hematopoeisis. A translocation between this locus and the T cell receptor beta locus (GeneID 6957) on chromosome 7 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Sep 2010],

Function：disease:A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein.,

Subcellular Location：Nucleus .

Expression： Lymph,