Target：LZTR1

Gene Name：LZTR1 TCFL2

Protein Name：Leucine-zipper-like transcriptional regulator 1 (LZTR-1)

Human Gene Id：8216

Human Swiss Prot No：Q8N653

Mouse Swiss Prot No：Q9CQ33

Immunogen：Synthesized peptide derived from human protein . at AA range: 310-390

Specificity：LZTR1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：92kD

Background： This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome. [provided by RefSeq, Jul 2008],

Function：developmental stage:Expressed in fetal brain, heart, kidney, liver and lung.,disease:May play a part in the etiology of the velocardiofacial/DiGeorge syndrome (VCFS/DGS), a developmental disorder characterized by structural and functional palate anomalies, conotruncal cardiac malformations, immunodeficiency, hypocalcemia, and typical facial anomalies. Most cases result from a deletion of chromosome 22q11.2 (the DiGeorge syndrome chromosome region, or DGCR).,function:Probable transcriptional regulator that may play a crucial role in embryogenesis.,similarity:Contains 2 BTB (POZ) domains.,similarity:Contains 6 Kelch repeats.,

Subcellular Location：Endomembrane system . Recycling endosome . Golgi apparatus .

Expression： Brain,Duodenal adenocarcinoma,Fetal brain,