Target：LZK

Fields：MAPK signaling pathway

Gene Name：MAP3K13

Protein Name：Mitogen-activated protein kinase kinase kinase 13

Human Gene Id：9175

Human Swiss Prot No：O43283

Mouse Gene Id：71751

Mouse Swiss Prot No：Q1HKZ5

Immunogen：The antiserum was produced against synthesized peptide derived from human M3K13. AA range:151-200

Specificity：LZK Polyclonal Antibody detects endogenous levels of LZK protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MAP3K13;LZK;Mitogen-activated protein kinase kinase kinase 13;Leucine zipper-bearing kinase;Mixed lineage kinase;MLK

Observed Band(KD)：108kD

Background： The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by autophosphorylation and homodimerization.,function:Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.,PTM:Autophosphorylated on serine and threonine residues.,sequence caution:Translated as Tyr.,sequence caution:Wrong choice of CDS.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Homodimer; forms dimers through the leucine-zipper motif. Interacts with the C-terminus of MAPK8IP

Subcellular Location：Cytoplasm . Membrane ; Peripheral membrane protein .

Expression：Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas.