Target：GNDS

Fields：Ras signaling pathway;Rap1 signaling pathway;Phospholipase D signaling pathway;Pathways in cancer;Colorectal cancer;Pancreatic cancer;Choline metabolism in cancer

Gene Name：RALGDS KIAA1308 RGF

Protein Name：Ral guanine nucleotide dissociation stimulator (RalGDS) (Ral guanine nucleotide exchange factor) (RalGEF)

Human Gene Id：5900

Human Swiss Prot No：Q12967

Mouse Swiss Prot No：Q03385

Rat Swiss Prot No：Q03386

Immunogen：Synthesized peptide derived from human protein . at AA range: 130-210

Specificity：GNDS Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：100kD

Background： Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010],

Function：domain:The Ras-associating domain interacts with Ras.,function:Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 Ras-GEF domain.,subunit:Interacts with RIT1 and RIT2.,

Subcellular Location：Cytoplasm . Nucleus . Localizes mainly in the peripheral region of the cytoplasmic membrane in oocytes and in preimplantation embryos until the 8-cell stage. Between the late 1-cell and the early 2-cell stages, nuclear localization becomes stronger. After the 4-cell stage, not detected in the nucleus. .

Expression： Brain,Epithelium,Placenta,Primary B-Cells,Spleen,Thalamus,