Target：CD297

Gene Name：ART4 DO DOK1

Protein Name：Ecto-ADP-ribosyltransferase 4 (EC 2.4.2.31) (ADP-ribosyltransferase C2 and C3 toxin-like 4) (ARTC4) (Dombrock blood group carrier molecule) (Mono(ADP-ribosyl)transferase 4) (NAD(P)(+)--arginine ADP-ri

Human Gene Id：420

Human Swiss Prot No：Q93070

Mouse Gene Id：109978

Mouse Swiss Prot No：Q9CRA0

Immunogen：Synthetic peptide from human protein at AA range: 181-230

Specificity：The antibody detects endogenous CD297

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：Ecto-ADP-ribosyltransferase 4 (EC 2.4.2.31;ADP-ribosyltransferase C2 and C3 toxin-like 4;ARTC4;Dombrock blood group carrier molecule;Mono(ADP-ribosyl)transferase 4;NAD(P)(+)--arginine ADP-ribosyltransferase 4;CD antigen CD297)

Background： This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. [provided by RefSeq, Jul 2008],

Function：catalytic activity:NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.,catalytic activity:NADP(+) + protein-L-arginine = nicotinamide + N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine.,online information:Blood group antigen gene mutation database,polymorphism:DO is responsible for the Dombrock blood group system. The molecular basis of the Do(a)/Do(b) blood group antigen is a single variation in position 265; Asn-265 corresponds to Do(a) and Asp-265 to Do(b). It is also responsible for the antigens Gregory [Gy(a)], Holley [Hy] and Joseph [Jo(a)].,similarity:Belongs to the Arg-specific ADP-ribosyltransferase family.,tissue specificity:Expressed in spleen and T-cells.,

Subcellular Location：Cell membrane; Lipid-anchor, GPI-anchor.

Expression：Expressed in spleen and T-cells.