Target：CD236
Fields：Malaria
Gene Name：GYPC GLPC GPC
Protein Name：Glycophorin-C (Glycoconnectin) (Glycophorin-D) (GPD) (Glycoprotein beta) (PAS-2') (Sialoglycoprotein D) (CD antigen CD236)
Human Gene Id：2995
Human Swiss Prot No：P04921
Mouse Gene Id：71683
Mouse Swiss Prot No：Q78HU7
Immunogen：Synthetic peptide from human protein at AA range: 11-60
Specificity：The antibody detects endogenous CD236
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：Glycophorin-C (Glycoconnectin;Glycophorin-D;GPD;Glycoprotein beta;PAS-2';Sialoglycoprotein D;CD antigen CD236)
Background： Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012],
Function：function:This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin C plays an important role in regulating the stability of red cells.,online information:Blood group antigen gene mutation database,online information:Glycophorin C entry,polymorphism:GYPC is responsible for the Gerbich blood group system.,subcellular location:Linked to the membrane via Band 4.1.,tissue specificity:Glycophorin C is expressed in erythrocytes. Glycophorin D is ubiquitous.,
Subcellular Location：Cell membrane; Single-pass type III membrane protein. Linked to the membrane via band 4.1.
Expression：Glycophorin-C is expressed in erythrocytes. Glycophorin-D and IsoGPC are ubiquitously expressed.
