Target：CD206

Fields：Phagosome;Tuberculosis

Gene Name：MRC1

Protein Name：Macrophage mannose receptor 1

Human Gene Id：4360

Human Swiss Prot No：P22897

Mouse Gene Id：17533

Mouse Swiss Prot No：Q61830

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human MRC1. AA range:341-390

Specificity：CD206 Polyclonal Antibody detects endogenous levels of CD206 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MRC1;CLEC13D;CLEC13DL;MRC1L1;Macrophage mannose receptor 1;MMR;C-type lectin domain family 13 member D;C-type lectin domain family 13 member D-like;Macrophage mannose receptor 1-like protein 1;CD206

Observed Band(KD)：170kD

Background： The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015],

Function：function:Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.,miscellaneous:CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.,online information:Macrophage mannose receptor,similarity:Contains 1 fibronectin type-II domain.,similarity:Contains 1 ricin B-type lectin domain.,similarity:Contains 8 C-type lectin domains.,

Subcellular Location：Endosome membrane ; Single-pass type I membrane protein . Cell membrane ; Single-pass type I membrane protein .

Expression： Milk,Placenta,Testis,