Target：CD107b

Fields：Autophagy - animal;Lysosome;Phagosome;Tuberculosis

Gene Name：LAMP2

Protein Name：Lysosome-associated membrane glycoprotein 2

Human Gene Id：3920

Human Swiss Prot No：P13473

Mouse Swiss Prot No：P17047

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human LAMP2. AA range:121-170

Specificity：CD107b Polyclonal Antibody detects endogenous levels of CD107b protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：LAMP2;Lysosome-associated membrane glycoprotein 2;LAMP-2;Lysosome-associated membrane protein 2;CD107 antigen-like family member B;CD107b

Observed Band(KD)：100kD

Background： The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008],

Function：disease:Defects in LAMP2 are the cause of Danon disease (DAND) [MIM:300257]; also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes.,function:Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter-and intracellular signal transduction.,PTM:O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.,similarity:Belongs to the LAMP family.,subcellular location:This protein shuttles between lysosomes, endosomes, and the plasma membrane.,tissue specificity:Isoform LAMP-2A

Subcellular Location：Cell membrane ; Single-pass type I membrane protein . Endosome membrane ; Single-pass type I membrane protein . Lysosome membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, autophagosome membrane . This protein shuttles between lysosomes, endosomes, and the plasma membrane.

Expression：Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle (PubMed:7488019, PubMed:26856698). Isoform LAMP-2B is detected in spleen, thymus, prostate, testis, small intestine, colon, skeletal muscle, brain, placenta, lung, kidney, ovary and pancreas and liver (PubMed:7488019, PubMed:26856698). Isoform LAMP-2C is detected in small intestine, colon, heart, brain, skeletal muscle, and at lower levels in kidney and placenta (PubMed:26856698).