Target：CCK-AR

Fields：Calcium signaling pathway;Neuroactive ligand-receptor interaction;Insulin secretion;Pancreatic secretion

Gene Name：CCKAR

Protein Name：Cholecystokinin receptor type A

Human Gene Id：886

Human Swiss Prot No：P32238

Mouse Gene Id：12425

Mouse Swiss Prot No：O08786

Rat Gene Id：24889

Rat Swiss Prot No：P30551

Immunogen：The antiserum was produced against synthesized peptide derived from human CCKAR. AA range:215-264

Specificity：CCK-AR Polyclonal Antibody detects endogenous levels of CCK-AR protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CCKAR;CCKRA;Cholecystokinin receptor type A;CCK-A receptor;CCK-AR;Cholecystokinin-1 receptor;CCK1-R

Observed Band(KD)：44kD

Background： This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008],

Function：function:Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.,online information:Cholecystokinin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression： Gall bladder,Peripheral blood leukocyte,Stomach,