Target：CBPD

Gene Name：CPD

Protein Name：Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180)

Human Gene Id：1362

Human Swiss Prot No：O75976

Mouse Swiss Prot No：O89001

Rat Swiss Prot No：Q9JHW1

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：CBPD Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：151kD

Background：carboxypeptidase D(CPD) Homo sapiens The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008],

Function：catalytic activity:Releases C-terminal Arg and Lys from polypeptides.,cofactor:Binds 2 zinc ions per subunit.,domain:There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity.,similarity:Belongs to the peptidase M14 family.,tissue specificity:Highly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal muscle, heart and colon carcinoma and melanoma cell lines.,

Subcellular Location：Cell membrane ; Single-pass type I membrane protein .

Expression：Highly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal muscle, heart and colon carcinoma and melanoma cell lines.