Target：CBP80

Fields：Nucleocytoplasmic transport;mRNA surveillance pathway;Spliceosome;Amyotrophic lateral sclerosis

Gene Name：NCBP1

Protein Name：Nuclear cap-binding protein subunit 1

Human Gene Id：4686

Human Swiss Prot No：Q09161

Mouse Gene Id：433702

Mouse Swiss Prot No：Q3UYV9

Rat Gene Id：298075

Rat Swiss Prot No：Q56A27

Immunogen：The antiserum was produced against synthesized peptide derived from human NCBP1. AA range:1-50

Specificity：CBP80 Polyclonal Antibody detects endogenous levels of CBP80 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NCBP1;CBP80;NCBP;Nuclear cap-binding protein subunit 1;80 kDa nuclear cap-binding protein;CBP80;NCBP 80 kDa subunit

Observed Band(KD)：80kD

Background： The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008],

Function：function:Involved in mediating U snRNA export from the nucleus. Binds to 5' capped mRNA.,similarity:Belongs to the NCBP1 family.,similarity:Contains 1 MIF4G domain.,subunit:Found in a U snRNA export complex with RNUXA/PHAX, CBP20, CBP80, RAN, XPO1 and m7G-capped RNA. Interaction with RNUXA/PHAX (By similarity). Heterodimer with NCBP2. Is part of the exon junction complex (EJC) containing NCBP1, NCBP2, RNPS1, RBM8A, SRRM1, NXF1, UPF3B, UPF2, THOC4 and/or REFBP2.,

Subcellular Location：Nucleus . Cytoplasm . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. .

Expression： Brain,Epithelium,Placenta,